I don't have biologics for COPD per se, but I have been on different biologics for over 20 years and know many people who have. They have been a game changer in a number of cases that I've known personally, and although it may take time to find the right one, it can be worth it. There are side effects, like any medication, but you can talk to the doctor about that and see if it's right for you! Keep on keepin' on, DPM