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My wife has used Breztri for her Asthma, but I have not for my COPD. I have used Trelegy and had to stop due to constant thrush, even though I gargled and rinsed after using it. My wife was upset when her work changed insurance and the new insurance would not cover Breztri. She like it an it worked well for her. I think you will like it. Just remember to gargle and rinse after using it and you will be ok. I used Symbicort, and now am on Bevespi. Also taking the bi-weekly Dupixent injections. Let the forum know how it works for you. Take care and God Bless!