Stiolto Respimat (tiotropium bromide and olodaterol)

Stiolto Respimat is a combination therapy for COPD containing a long-acting muscarinc agent (LAMA) or anticholinergic, tiotropium and a long-acting beta2-adrenergic agonist (LABA), olodaterol. Stiolto Respimat is a long-term, maintenance treatment and should not be used as a rescue medicine for treating sudden breathing problems.

What are the ingredients in Stiolto Respimat?

The two active ingredients in Stiolto Respimat are tiotropium bromide and olodaterol.

How does Stiolto Respimat work?

Stiolto Respimat contains two active mechanisms to manage COPD symptoms: anticholinergic, tiotropium and LABA, olodaterol. Both help the muscles around the airways in the lungs stay relaxed to prevent symptoms such as wheezing, coughing, chest tightening and shortness of breath.

What are the possible side effects of Stiolto Respimat?

For patients in clinical trials that were treated with Stiolto Respimat, common side effects included:

  • Cold symptoms
  • Cough
  • Back pain

Patients with urinary retention (difficult and painful urination) and glaucoma (eye pain/redness, blurred vision, vision changes) may experience worsening of symptoms and should consult their doctors immediately if any of these signs develop.

Other side effects caused by treatment with Stiolto Respimat include: heart problems (palpitations, irregular heartbeat, chest pain, high blood pressure) high blood glucose levels and low blood potassium levels. These are not all the possible side effects of Stiolto Respimat. Patients should talk to their doctor about what to expect with treatment with Stiolto Respimat.

Things to know about Stiolto Respimat

Stiolto Respimat should not be used to treat patients with asthma.

Before starting Stiolto Respimat, patients should tell their healthcare professionals about all medical conditions, particularly if they:

  • Have heart problems
  • Have high blood pressure
  • Have seizures
  • Have thyroid problems
  • Have diabetes

While on Stiolto Respimat, other medicines containing LABA or anticholinergics should not be used. Before starting treatment with Stiolto Respimat, patients should talk to their doctor about all medications (prescription and over-the-counter), herbal supplements, and vitamins they are taking. Certain medications may interact with Stiolto Respimat and may cause serious side effects. Patients should tell their doctor if they are pregnant, plan to become pregnant, or are breastfeeding since it is not known if Stiolto Respimat can harm an unborn baby or pass into breast milk.

People with asthma who take LABA medicines such as olodaterol, the active ingredient in Stiolto Respimat, have an increased risk of death from asthma problems. Do not take Stiolto Respimat for asthma.

Dosing information

Stiolto Respimat should be taken every day as 2 inhalations, once daily, at the same time of the day. Do not take more than one dose in 24 hours. Each inhalation contains 2.5mcg of tiotropium and 2.5mcg of olodaterol.

For more information, read the full prescribing information for Stiolto Respimat.

Written by: Amna Rizvi | Last reviewed: April 2018
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