. Hi. 'm not an expert on nitric oxide, but I can share some insights. It was used in my hospital for sedation purposes in the past, although it's not used for that anymore. The effects of inhaled nitric oxide are generally short-lived. However, naturopathic doctors often recommend supplements like L-arginine or beetroot powder to help boost your body's own production of nitric oxide, which might offer some benefits. For more personalized advice, especially regarding its impact on oxygen saturation or fatigue, it’s best to consult with a healthcare professional. What do you think? John. community moderator.