dupixent
unresponsive to Breztri and trilogy. anybody out there with good results from Dupixent?
Hi
, thank you for reaching out! I hear how frustrating it feels to not have your symptoms respond to either Breztri or Trelegy when those are often considered the "cadillac inhalers" for COPD. Dupixent is a biologic that I believe is in the clinical trial phase for COPD but is not yet FDA approved as a COPD treatment. Biologics are showing promise for COPD, but none are yet approved to be prescribed specifically for COPD. It may be that a few in the community who have asthma overlap are prescribed a biologic as some biologics, including Dupixent, are approved for asthma treatment. I thought this article might be of interest to you: https://copd.net/living/talking-biologics Have you had a conversation with your doctor about your lack of response to the triple inhalers? What are they recommending for you at this time? Please keep us posted on how you are managing! Know we are here to listen when you need a friendly ear. Wishing you a gentle day. ~Allyson (COPD.net team)
doctor has referred me to a neurologist. Any thoughts on and inhaler that might work when the Brextri and Trelegy did not?
My doctor has referred me to a neurologist or more or less given up from her end as the Breztri and Trelegey don't work. any thoughts on a different type inhaler that might work when those two do not?
do you know of any examples of an inhaler that works when Breztri and Trilogy were ineffective? 
Hi jemik and thanks for responding. As you may be aware, medications and their effectiveness can vary from patient to patient. Having said that, medications that work for one patient (in combination with other medications or by themselves), can also vary considerably among patients. The challenge of finding a medication that works for you (when Breztri and Trelegy do not), is something for you to work out with your physician. Understanding that your physician has redirected you to a neurologist can make this even more challenging.
I have worked with any number of patients who have had success with various combination therapy (inhalers, systemic medications, intravenous medications, etc.), and this is something, too, that has to be directed, monitored, and overseen by one's private medical doctor. I am purposely not mentioning any medications by name, since I do not want to mislead you nor do I think this can be resolved by a patient alone. A physician is the key to overseeing one's treatment and care.
Wishing you well,
Leon (site moderator COPD.net)
basically after her referral to cardiologist for heart test that showed everything ok she kinda just gave up? said those those the medicines were the best she had to offer.
I hear what a difficult time you are having with your doctor. Like my colleague , I am confused as to why you are being referred to a neurologist. For finding the best lung treatment for managing your COPD, I would encourage you to ask for a referral to a pulmonologist. As lung specialists, they will have the most knowledge about options for helping you manage your COPD. Just because the "best" and newest treatment options are not effective for you does not mean other options that have been around longer won't help either! There are definitely other things your doctor can try. A pulmonologist would be a good place to start the process of trying other treatment options. We cannot offer specific medical advice or treatment recommendations over the internet (for your safety!) however, we do have articles about most of the inhaler options for COPD. The best way to access these is to look above at the black menu bar at the top of the page. Click on the Menu dropdown. You will see a white, bolded heading for "Treatment." Select that option and then "Medications." That provides an entire list of specific articles about different medication options. I will also try to attach a screenshot of the dropdown!
I hope this is helpful for you! Please keep us posted on how you are managing. Know we are here to listen when you need support. Wishing you a gentle day. ~Allyson (COPD.net team)
Hi again, jemik - thanks for letting us know that you have also been referred to a cardiologist. It sounds like your doctor, after hearing (from the cardiologist), that your heart was okay, seemed to have backed away from your further care. Is this when she referred you to a neurologist?
I see my good colleague,, has provided some excellent information about accessing the various medications that can be used in the treatment of COPD. Reviewing these on your own may help you to prepare to see a pulmonologist. As Allyson has indicated (and I concur), a pulmonologist would be the best specialist/doctor for you to see in order to further your own treatment. It remains unclear (to me), why you were referred to a neurologist.
Please know we are all trying to be of help and support as you seek out additional medical care through the right set of physicians.
Please do check back and keep us apprised of your progress. We have a genuine concern for your good health!
Warmly,
Leon (site moderator COPD.net)
