For me, there are two things to consider with this question. One is that with the onset of serious COPD my range of motion is much decreased. Second is that cramps, spasms, and other muscle issues are closely related to oxygenation in those tissues. Stretching, exercise, and getting enough oxygen are keys to dealing with these problems for me. Sometimes it's simple and sometimes not so much. My newly limited range of motion affects my sleeping position, too, which feeds the problem. I need to find new ways to get the stretching and exercise I need that will be enough to have balance, and it's a battler, every day, but I need to stay in it to win. Some days it's easy and other days it seems impossible. But, if I pull a muscle or otherwise somehow injure myself, it's usually from trying to do something I shouldn't have, or getting too rambunctious in the attempt, or making one little mistake. Then I pay dearly for it. Like my currently broken toe, which I continue to whack on things almost daily, or not drinking enough water daily, which is my tendency, because I hate all those constant trips to the bathroom. It's hard to strike a balance that works well enough to prevent the cramps. Enough that I have yet to succeed. It's a different world I live in now, and I am having some difficulties with the adjustment!