This is great advancement is stem cell science. Now we need to progress to human studies.
Rationale: The regeneration and replacement of lung cells or tissues from induced pluripotent stem cell– or embryonic stem cell–derived cells represent future therapies for life-threatening pulmonary disorders but are limited by technical challenges to produce highly differentiated cells able to maintain lung function. Functional lung tissue–containing airways, alveoli, vasculature, and stroma have never been produced via directed differentiation of embryonic stem cells (ESCs) or induced pluripotent stem cells. We sought to produce all tissue components of the lung from bronchi to alveoli by embryo complementation.
Conclusions: Lung and thyroid tissues were generated in vivo from ESCs by blastocyst complementation.