Hi SamI, and thank you for your post. I see my colleague, , has already replied to your inquiry with a link to a helpful article on the topic of flare-ups/exacerbations. I do hope you find it to be helpful.
I also notice that you mentioned a clinical symptom presentation, known as cyanosis. This generally presents as a blueish color of the fingers and/or toes, and lips, and can be indicative of long standing oxygen deprivation. There are various medical conditions that may result in an cyanotic appearance. I thought this article, on that very subject, might provide you with some additional insight: https://copd.net/symptoms/blueness.
I do hope you find this material to be helpful as well.
All the best,
Leon (site moderator COPD.net)