Hi. I am not on prednisone long-term myself. Although, I am aware of people who do take prednisone on a daily basis. My dad takes it for arthritis. And it seems to work well for him. He has not mentioned side effects. Because it is so helpful for arthritis, it has been well studied and shown to be safe at low doses (such as 5 mg). With COPD, though, it has been linked to a slightly increased risk for getting pneumonia -- which may trigger COPD flare-ups. So, for this reason, long-term steroids are generally not recommended for COPD. However, in some cases of severe COPD, it may still be prescribed long-term if the benefits outweigh the risks.Is this what your doctor has talked to you about? John. community moderator.