Exacerbation while on Dupixent

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I really don't have an answer for that. All I can do is speculate. But it seems to me that the chance of any medication just ceasing to work after x amount of time, is pretty slim. I would be more inclined to think it is just a flare up. I know Dupixent is supposed to prevent flare ups more than other meds, but there is no guarantee with any medication and COPD. Riding your electric bike for 35 minutes in 56 degree weather seems like it would cause some problems. The temperature compounded with the speed of the bike probably made the temp a bit lower for your lungs and a little harder to breathe than you realized. I am on Bevespi and it works very well for me. I can go several months feeling great and then, wham-o, I get a flare up. You have to remember that your breathing on that particular day may have seemed fine. But your lungs did not think so. The damaged lung tissue gets inflamed and makes you miserable. When the inflammation occurs, it does not show up immediately. It may take several days to rear it's ugly head. Prednisone is good to calm down the inflammation and get any swelling under control. I do not really dread Prednisone, although too much can cause problems. Please keep the forum updated as to the prognosis and treatment. We all can learn from each others experiences and it is helpful. Take care and God Bless!

Thank you so much for the feedback. Where I have always gone wrong is trying to exercise like I did before my diagnosis. I had several flares because of this. After Dupixent, it seemed like I could tone it down some but still do it.
I was walking a mile almost everyday. The electric bike helped me to lessen the effort but still get a good workout. Now I don’t know what to do. My doctor isn’t into exercise (haha), so he could not help me regarding this.
Anyways thanks again.

Dminor9 has always posted well, thanks again. I tend to agree, sometimes we seem to forget that we are really, really sick, and when we feel good, it makes it harder on us in the future. We overextend. I know I do, and am feeling it right now as I am writing. All will be well, stretching the rubber band and then *SNAP* you reached your limit and get pulled back into 'this sucks'. As for the exercise, there are a lot of article in here that promotes it and help give some guidance as well. I try to follow the printed instructions, but, you know guys, we don't need them, or maps, or any other instructions that will help us. It is who we are. Until we aren't, and then I find it is usually ending with an exasperation. Best wishes, keep yer stick on the ice.

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Good post and great point Southpaw. By the way, I am also lefthanded and a hockey fan. Over doing exercise is too easy to do and always makes us suffer. I have got an exercise routine down pat for myself. It does take a bit of experimenting to figure out what is too much and what is just enough. I walk back and forth through the kitchen, into the dining room, and to the front door two to three times. Then I do overhead presses with 5 pound dumbbells for 15-20 reps (depending how I feel). Then a two minute rest or more to catch my breathe. Then I do the walk routine again, followed by upright rows or single hand bent over rows with the 5 pound dumbbells. 15-20 reps, followed by calf raises for 15 reps. Rest again. Repeat the walking, then do Arnie shoulder raises with the dumbbells for 15 reps. Followed by calf raises with feet pointed to the side for 15 reps. Rest. Arnie raises are dumbbells held with wrists facing your head and arms by the side of your head. As you raise your arms, you turn your arm towards the front so your wrists and palms face away from you. You can look it up if confused. I then walk again followed by bicep curls for 15-20 reps. Then I am done. I try to do this 5 days a week. It takes about 30 minutes. I clean the house once a week. This takes a couple hours with resting in between dusting, vacuuming, and wet mopping. Some days I do Qi Dong (a form of Tai Chi) for breathing and stretching. You have to find a routine that works for you without over doing it. The key is taking your time and resting in between. Take your time and go slow. There is no reason to rush. If you get out of breathe, stop and rest until you catch your breathe. Exercise is definitely important, but no single way to do it works for everyone. Take care and God Bless!