Hi Lacie4460 and thanks for your post and question. While I hope others in the community will see your inquiry and respond, I thought I would chime in as well. It is feasible to exercise with or without oxygen. If a patient has supplemental oxygen prescribed by a physician, it is probably better for them to exercise utilizing the oxygen. This is something you may want to discuss further with your mom's physician. Wishing you the best, Leon (site moderator)