Breztri Aerosphere™ Approved to Treat COPD

Breztri Aerosphere is a single-inhaler, fixed-dose combination of 3 drugs that has been approved by the FDA for the maintenance treatment of COPD. It was formerly known as PT010.¹

What are the ingredients in Breztri Aerosphere?

The active ingredients in Breztri Aerosphere include:²

• Micronized budesonide
• Micronized glycopyrrolate
• Micronized formoterol fumarate

How does Breztri Aerosphere work?

The active ingredients in Beztri Aerosphere work together to help reduce COPD symptoms and flare-ups.² Micronized budesonide is an inhaled corticosteroid that helps reduce inflammation in the lungs. Inflammation can lead to breathing problems.²

Micronized glycopyrrolate is an anticholinergic drug. Micronized formoterol fumarate is a long-acting beta2-adrenergic agonist (LABA) drug. These are types of drugs that help relax the muscles around the airways. This helps reduce symptoms like wheezing, cough, shortness of breath, and chest tightness. All of these can make it harder to breathe.²

What are the possible side effects of Breztri Aerosphere?

The most common side effects of Breztri Aerosphere include:²

• Back pain
• Feelings of anxiety
• Flu
• Headache
• Heart palpitations
• High blood sugar
• Joint pain
• Muscle spasms
• Nausea or diarrhea
• Painful or frequent urination
• Pneumonia
• Sinus inflammation
• Thrush in the mouth or throat
• Trouble sleeping
• Upper respiratory tract infections

Other less common side effects include:²

• Allergic reactions, including hives or rash
• Bone thinning or weakness
• Fatigue or feelings of weakness
• New or worsening eye problems, including cataracts, eye pain, or blurred vision
• Sudden breathing problems
• Tremors or feelings of nervousness
• Weakened immune system

These are not all the possible side effects of Breztri Aerosphere. Talk to your doctor about what to expect or if you experience any changes that worry you.

Things to know about Breztri Aerosphere

Breztri Aerosphere is not for treating asthma. It should not be used to relieve sudden breathing problems and will not replace a rescue inhaler.² People who are allergic to budesonide, glycopyrrolate, or formoterol should not use Breztri Aerosphere.²

Talk to your doctor about taking Breztri Aerosphere if you are using other products containing:²

• Anticholinergic medications
• Other LABAs
• Atropine
• Antifungal medications
• Anti-HIV drugs

Other considerations

Tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.² It is not known if Breztri Aerosphere is safe and effective for children.²

There is not enough information about Breztri Aerosphere and pregnancy to know if this drug is safe to use when pregnant. The risk of birth defects and miscarriage is not known. Prior to using this drug, tell your doctor if you are pregnant or plan to become pregnant.² It is not known whether this drug is safe to take while breastfeeding. Women who are breastfeeding should talk to their doctor before taking Breztri Aerosphere.²

Talk with your doctor about all of your medical and health conditions or problems before starting Breztri Aerosphere. This medication may not be right for everyone and may worsen some health conditions. You and your doctor can go over all of the possible side effects and decide whether it is an appropriate medication for you now.

For more information, read the full prescribing information of Breztri Aerosphere.