Bevespi Aerosphere (glycopyrrolate/formoterol fumarate) Inhalation Aerosol

Reviewed by: HU Medical Review Board | Last reviewed: February 2022 | Last updated: September 2021

Bevespi Aerosphere (glycopyrrolate/formoterol fumarate) is an inhalation aerosol used for the long-term maintenance treatment of airflow obstruction in people with COPD. It is a bronchodilator.1,2

Bronchodilators are used to prevent and treat chronic obstructive pulmonary disease (COPD). They work by relaxing the muscles in the airways (bronchi). This widens the airways, allowing more air to travel in and out of the lungs.1

What are the ingredients in Bevespi Aerosphere?

The active ingredients in Bevespi Aerosphere are glycopyrrolate and formoterol fumarate.2

How does Bevespi Aerosphere work?

The active ingredients in Bevespi Aerosphere work to reduce COPD symptoms:2

  • Glycopyrrolate is a long-acting antimuscarinic agent (LAMA). It works by relaxing smooth muscles in the airways. This makes breathing easier.
  • Formoterol fumarate is a long-acting, selective beta2-adrenergic agonist. It also acts as a bronchodilator to relax the smooth muscle in the airways. Formoterol fumarate may also be called a long-acting bronchodilator, or LABA.

What are the possible side effects of Bevespi Aerosphere?

The most common side effects of Bevespi Aerosphere are urinary tract infection (UTI) and cough.2

Bevespi Aerosphere may also cause serious side effects, including:2

  • Allergic reactions like rash, hives, or breathing problems
  • New or worsening eye problems
  • Increased blood pressure
  • Fast or irregular heartbeat
  • Chest pain
  • Tremors
  • High blood sugar
  • Low potassium levels
  • Difficult or painful urination

If your breathing problems quickly worsen after taking Bevespi Aerosphere, contact 9-1-1 right away.

These are not all the possible side effects of Bevespi Aerosphere. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Bevespi Aerosphere.

Things to know about Bevespi Aerosphere

Do not use Bevespi Aerosphere if you are allergic to glycopyrrolate, formoterol fumarate, or any other ingredients in this drug.2

Bevespi Aerosphere should not be used for the treatment of asthma. LABA drugs like formoterol fumarate increase the risk of asthma-related death.2

Bevespi Aerosphere should not be used in combination with another LABA medicine or an anticholinergic because of the risk of overdose.2

Bevespi Aerosphere should not be used for acute symptoms of COPD. People taking Bevespi Aerosphere should have a rescue inhaler for sudden symptoms.2

Before taking Bevespi Aerosphere, tell your doctor if you have:2

  • Heart problems
  • High blood pressure
  • Seizures
  • Thyroid problems
  • Diabetes
  • Liver problems
  • Glaucoma
  • Prostate or bladder problems

There is not enough data to know if Bevespi Aerosphere is safe to take while pregnant or breastfeeding. Before taking this drug, tell your doctor if you are pregnant, plan to become pregnant, or breastfeeding.2

Bevespi Aerosphere may interact with other medicines. Before beginning treatment for COPD, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information for Bevespi Aerosphere.

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