I would be interested to hear more on the affects that these have on COPD. For me, these also flared up when I had a COPD exacerbation. I had acidic fluid flushing up in my throat and small amounts would enter my upper lungs and of course cause coughing. I am on Nexium now and it has settled down substantially and also am different inhalers which seem to be doing a better job. Still pretty new at this since my diagnosis end of January. I've had my first pretty good week and if this is as good as it gets for me now, I'm fine with it. Still adjusting to the limitations that I come up against unexpectedly as I discover this "new" way of living. I am going to have an Upper GI x-ray in the morning to assess my hiatus hernia. It's been 30 years since last x-ray. On the bright side, if surgery is necessary, at least it's a lot more pleasant than considering it for a brief second 30 years ago!!