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COPD does not necessarily cause muscle cramps in and of itself at night. There are several things that can also cause the night cramps. Dehydration, not enough electrolytes, low magnesium, side effects of meds (Symbicort has this side effect), among others. I make sure I drink plenty of water during the day, I drink at least one bottle of sports drink daily for electrolytes, I eat at least one banana for potassium, take daily vitamins for minerals, and exercise to keep muscles toned and loose. Some people drink tonic water daily for the quinine, which is supposed to help muscle cramps. You should contact your medical team and talk to them about your cramping problem. I am sure they will give you a good solution to the problem. Good luck and Take Care.