Breztri Aerosphere™ (budesonide, glycopyrrolate, formoterol fumarate)

Reviewed by: HU Medical Review Board | Last reviewed: May 2023 | Last updated: July 2023

Chronic obstructive pulmonary disease (COPD) damages the lungs and makes it hard to breathe. Breztri Aerosphere® is an inhaled drug used to treat the symptoms of COPD.1

Breztri Aerosphere is a long-term treatment option. It helps the muscles around your airways relax, which can lessen symptoms like:1

What are the ingredients in Breztri Aerosphere?

The active ingredients in Breztri Aerosphere are:1

  • Micronized budesonide
  • Micronized glycopyrrolate
  • Micronized formoterol fumarate

How does Breztri Aerosphere work?

People with COPD often have trouble breathing because the muscles around their airways constrict, or tighten. Breztri Aerosphere relaxes these muscles to make breathing easier.1

Breztri Aerosphere is a combination of a long-acting muscarinic antagonist (LAMA), a long-acting beta-2 agonist (LABA), and an inhaled corticosteroid (ICS).1

LAMAs and LABAs relax the muscles in the airways. ICS drugs reduce inflammation and swelling to increase airflow in the airways. This combination reduces the symptoms of COPD.1

What are the possible side effects?

Side effects with Breztri Aerosphere are uncommon but may include:1

  • Upper respiratory tract infection
  • Pneumonia
  • Back pain
  • Join paint
  • Flu
  • Headache
  • Fungal infection (thrush) in your mouth and throat

To prevent thrush, rinse your mouth with water after using Breztri Aerosphere.1

These are not all the possible side effects of Breztri Aerosphere. Talk to your doctor about what to expect when taking Breztri Aerosphere. You also should call your doctor if you have any changes that concern you when taking Breztri Aerosphere.

Other things to know

Breztri Aerosphere is a long-term treatment option for people with COPD. It is not meant to treat sudden COPD symptoms or flare-ups. If you are having a flare-up, contact your doctor. They may prescribe a rescue inhaler. If you are having sudden, extreme problems breathing, seek emergency care.1

There is not enough data from the research to know if Breztri Aerosphere is safe to use in pregnant or breastfeeding people. Before using this drug, tell your doctor if you are pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed.1

Before beginning treatment for COPD, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs. Make special note of:1

  • Other anticholinergic drugs (SAMAs or LAMAs)
  • Other LABAs
  • Atropine
  • Antifungal drugs
  • Anti-HIV drugs

For more information, read the full prescribing information of Breztri Aerosphere.

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