Breztri Aerosphere™ (budesonide/glycopyrrolate/formoterol fumarate)

Reviewed by: HU Medical Review Board | Last reviewed: August 2021 | Last updated: September 2021

Breztri Aerosphere™ (budesonide/glycopyrrolate/formoterol fumarate) is a single-inhaler, fixed-dose combination of 3 drugs approved for the maintenance treatment of COPD.1,2

What are the ingredients in Breztri Aerosphere?

The active ingredients in Breztri Aerosphere include:2

  • Micronized budesonide
  • Micronized glycopyrrolate
  • Micronized formoterol fumarate

How does Breztri Aerosphere work?

The active ingredients in Beztri Aerosphere work together to help reduce COPD symptoms and flare-ups. Micronized budesonide is an inhaled corticosteroid that helps reduce inflammation in the lungs. Inflammation can lead to breathing problems.2

Micronized glycopyrrolate is an anticholinergic drug. Micronized formoterol fumarate is a long-acting beta2-adrenergic agonist (LABA) drug. These are types of drugs that help relax the muscles around the airways. This helps reduce symptoms like wheezing, cough, shortness of breath, and chest tightness. All of these can make it harder to breathe.2

What are the possible side effects of Breztri Aerosphere?

The most common side effects include:2

  • Back pain
  • Diarrhea
  • Feelings of anxiety
  • Flu
  • Headache
  • Heart palpitations
  • High blood sugar
  • Joint pain
  • Muscle spasms
  • Nausea or diarrhea
  • Painful or frequent urination
  • Pneumonia
  • Sinus inflammation
  • Thrush in the mouth or throat
  • Trouble sleeping
  • Upper respiratory tract infections
  • Urinary tract infections

Other less common side effects include:2

  • Allergic reactions, including hives or rash
  • Bone thinning or weakness
  • Fatigue or feelings of weakness
  • New or worsening eye problems, including cataracts, eye pain, or blurred vision
  • Sudden breathing problems
  • Tremors or feelings of nervousness
  • Weakened immune system

These are not all the possible side effects of Breztri Aerosphere. Talk to your doctor about what to expect or if you experience any changes that worry you during treatment with Breztri Aerosphere.

Things to know about Breztri Aerosphere

Breztri Aerosphere is not for treating asthma. It should not be used to relieve sudden breathing problems and will not replace a rescue inhaler. People who are allergic to budesonide, glycopyrrolate, or formoterol should not use Breztri Aerosphere.2

Talk to your doctor about taking Breztri Aerosphere if you are using other products containing:2

  • Anticholinergic drugs
  • Other LABAs
  • Atropine
  • Antifungal drugs
  • Anti-HIV drugs

There is not enough data to know if Breztri Aerosphere is safe to use when pregnant or breastfeeding. Before using this drug, tell your doctor if you are pregnant, plan to become pregnant, or breastfeeding.2

Before beginning treatment for COPD, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Breztri Aerosphere.

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