Stiolto Respimat (tiotropium bromide and olodaterol)

Reviewed by: HU Medical Review Board | Last reviewed: December 2023

Stiolto Respimat® (tiotropium bromide and olodaterol) is an inhaled medicine. It contains both a long-acting muscarinic agent (LAMA) and a long-acting beta2-adrenergic agonist (LABA).1

Stiolto Respimat is a long-term maintenance treatment for chronic obstructive pulmonary disease (COPD). It should not be used as a rescue medicine for treating sudden breathing problems.1

What are the ingredients in Stiolto Respimat?

The active ingredients in Stiolto Respimat are tiotropium bromide (a LAMA) and olodaterol (a LABA).1

How does Stiolto Respimat work?

COPD can cause symptoms such as mucus, wheezing, cough, chest tightness, and shortness of breath. The drugs in Stiolto Respimat work together to manage these symptoms. Both drugs help the muscles around the airways in the lungs stay relaxed. This helps with breathing.1,2

Tiotropium bromide is a LAMA. LAMAs work by blocking the action of a chemical messenger called acetylcholine. This process relaxes muscles in the airways, which reduces the symptoms of COPD.1

Olodaterol is a LABA. LABAs work by stimulating B2 receptors. This process also relaxes muscles in the airways and reduces the symptoms of COPD.1

What are the possible side effects?

The most common side effects of Stiolto Respimat include:1

  • Cold symptoms
  • Cough
  • Back pain
  • Urinary retention, which could be severe
  • Eye redness, blurred vision, and vision changes, with or without pain
  • Heart problems
  • High blood pressure

Call 9-1-1 if your breathing suddenly worsens after taking Stiolto Respimat.1

These are not all the possible side effects of Stiolto Respimat. Talk to your doctor about what to expect when taking Stiolto Respimat. You also should call your doctor if you have any changes that concern you when taking Stiolto Respimat.

Other things to know

Before using Stiolto Respimat, tell your doctor if you have:1

  • Heart problems
  • Chest pain
  • High blood pressure
  • Seizures
  • Thyroid problems
  • Diabetes
  • Eye problems like glaucoma
  • Prostate or bladder problems

Stiolto Respimat should not be used to treat people with asthma.1

Stiolto Respimat is not a rescue inhaler and is not meant to treat sudden COPD exacerbations (flare-ups). Avoid using extra doses for such situations. If you have trouble breathing, Stiolto Respimat will not work right away. Talk to your doctor about rescue inhalers for quick relief of trouble breathing.1

Notify your doctor immediately if you experience1:1

  • Worsening COPD symptoms
  • Reduced effectiveness of rescue inhaler
  • Need for more inhalations than usual
  • A significant decrease in lung function

There is not enough data to know if Stiolto Respimat is safe to take while pregnant or breastfeeding. Before taking this drug, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. They can help you decide if Stiolto Respimat is right for you.1

While on Stiolto Respimat, you should not take other LABA or anticholinergic medicines. Certain medicines may interact with Stiolto Respimat and cause serious side effects. Talk to your doctor about the medicines you take before starting Stiolto Respimat.1

Before beginning treatment for COPD, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Stiolto Respimat.1

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