Prolastin-C (alpha1-proteinase inhibitor)

Prolastin-C is a treatment option for emphysema for those patients who have a severe deficiency of alpha1-PI (alpha1-antitrypsin deficiency). This medication comes in the form of Prolastin-C and Prolastin-C liquid. The ready-to-use liquid formulation offers no need for mixing before your infusion.1 Talk to your doctor about which option is right for you.

Some people are born with a rare genetic condition that is called alpha¬1 antitrypsin (AAT) deficiency. Having this condition causes a high risk of getting emphysema, especially if the person has ever smoked and even if they never have.

What are the ingredients in Prolastin-C?

The active ingredient in Prolastin-C is alpha1 proteinase inhibitor human.

How does Prolastin-C work?

AAT proteins are produced by the liver and travel through the bloodstream. One of their functions is to protect the lungs and other organs in the body from damage. Having AAT deficiency causes a person's liver to produce AAT proteins that are not the right shape to enter the bloodstream and protect the lungs. Without this natural kind of protection, irritants like cigarette smoke can cause severe damage to the person's lungs.

Prolastin-C is a concentrated form of AAT that is made from blood plasma. Prolastin-C can be effective at raising the levels of AAT protein in the bloodstream of a person with AAT deficiency.

What are the possible side effects of Prolastin-C?

For patients in clinical trials that were treated with Prolastin-C, the most common side effect was diarrhea, fatigue, cough, headache, upper respiratory infection, and dizziness.

Other side effects caused by treatment with Prolastin-C include: itching, swelling of legs and feet, increased liver enzymes, and chest discomfort. These are not all the possible side effects of Prolastin-C. Patients should talk to their doctor about what to expect with treatment with Prolastin-C.

Things to know about Prolastin-C

Prolastin-C therapy is only suitable for patients who have emphysema that is caused by AAT deficiency. It is not for use by people who have emphysema due to any other types of causes.

People with a type of genetic immune system condition called IgA deficiency should not take Prolastin-C, because it can cause an allergic reaction. Since Prolastin-C is made from human blood plasma, there is some risk of transmitting certain types of infectious agents, including viruses.

Other approved Alpha-1 Proteinase Inhibitors

Other approved Alpha-1 Proteinase Inhibitors include:

  • Aralast NP
  • Prolastin-C
  • Zemaira
For more information, read the full prescribing information of Prolastin-C.

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Written by: Amna Rizvi | Last reviewed: August 2020.