Skip to Accessibility Tools Skip to Content Skip to Footer

YUPELRI (revefenacin)

Yupelri (revefenacin) is an inhalation solution used as a maintenance treatment for chronic obstructive pulmonary disease (COPD). It is the only once-a-day nebulized long-acting muscarinic antagonist (LAMA), which provides for 24 hours of improvement in lung function for patients with COPD.1,2,3

Yupelri is part of a class of drugs for COPD called anticholinergics that block the action of a chemical messenger in the brain called a neurotransmitter. There are long-acting and short-acting anticholinergics. Yupelri is the long-acting type. Do not exceed the recommended dose. 1,2,3

Yupelri is a maintenance therapy for COPD and is not used for treating COPD flare-ups that have already started. Rescue inhalers should be used for symptoms that are very severe and need rapid relief.1,2,3

What are the ingredients in Yupelri?

The active ingredient in Yupelri is revefenacin.1,2,3

How does Yupelri work?

Yupelri, like other anticholinergics, helps to treat COPD symptoms by relaxing the muscles that surround the airways. It helps to prevent symptoms such as wheezing, cough, tightness in the chest, and shortness of breath.1 COPD can cause irritation in the lungs that makes muscles tighten up, which can make breathing symptoms worse.

Revefenacin, the medicine in Yupelri, is delivered by way of a single vial administered once each day inhaled through a nebulizer to improve symptoms of COPD for easier breathing.1 In clinical studies it has been shown to work in as little as 30 minutes.

What are the possible side effects of Yupelri?

The most common side effects of Yupelri are cough, runny nose, upper respiratory infection, headache, and back pain. This is not an exhaustive list of all potential side effects. Talk to your healthcare provider or pharmacist for further information.2,3

If you experience extreme breathlessness right after taking Yupelri, stop taking it and seek medical help immediately. A small number of people have difficulty urinating while taking Yupelri as it can cause urinary retention especially in men with benign prostatic hyperplasia (enlarged prostate gland) or bladder-neck obstruction (restriction of urinary flow).2,3

Things to know about Yupelri

Yupelri may interact with concomitantly used anticholinergic medications. It’s important to avoid taking Yupelri with other anticholinergic-containing drugs.2,3 Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Yupelri and certain other medicines may interact with each other.

If you experience an immediate hypersensitivity such as severe itching, swelling of the mouth tongue or face, or skin rash or hives after taking Yupelri, stop taking it and seek medical help immediately.2,3

Yupelri is not recommended for children, Tell your doctor if you:2,3

  • Have any preexisting hepatic (liver), prostate, or bladder problems
  • Are pregnant or planning to become pregnant
  • Are breastfeeding, as it is not known if the medicine in Yupelri enters the breast milk and if it can harm your baby
  • Have eye problems such as glaucoma, as this drug can make glaucoma worse

For people who already have narrow-angle glaucoma, it can cause that condition to get worse. Consult your health care provider if you develop symptoms such as eye pain and discomfort, blurry vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema.2,3

Yupelri can cause a life-threatening narrowing of the airways called paradoxical bronchospasm. If this occurs the condition should be treated immediately with an inhaled, short-acting bronchodilator, and Yupelri should be discontinued immediately. If this develops, consult your physician about alternative therapy.2,3

Dosing information

Yupelri is administered once a day. A 3ml vial of 175 mcg Yupelri is inhaled through a standard jet nebulizer connected to an air compressor and mouthpiece. It provides a full day of improvement for COPD symptoms. Yupelri is stored at room temperature and takes approximately 8 minutes to administer by breathing the medication through the nebulizer.2,3

For more details, read the full prescribing information of Yupelri.

Written by: Linda Saxl Minton | Last reviewed: August 2019.
  1. What is YUPELRI? Available at: https://www.yupelri.com/. Accessed 3.19.19.
  2. Prescribing Information. Available at: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?type=display&setid=6dfebf04-7c90-436a-9b16-750d3c1ee0a6. Accessed 3.19.19.
  3. Introducing Yupelri. Available at: https://www.yupelrihcp.com/?gclid=EAIaIQobChMIp6vvhpqR4QIVxlSGCh0glA_7EAAYASAAEgK3JfD_BwE. Accessed 3.19.19.