Yupelri (revefenacin)

Reviewed by: HU Medical Review Board | Last reviewed: February 2022 | Last updated: March 2022

Yupelri (revefenacin) is an inhalation solution used as a maintenance treatment for chronic obstructive pulmonary disease (COPD). It is a once-a-day nebulized, long-acting muscarinic antagonist (LAMA) that provides for 24 hours of improvement in lung function for people with COPD.1-3

Yupelri is part of a class of drugs for COPD called anticholinergics. These drugs block the action of a chemical messenger called acetylcholine. There are long-acting and short-acting anticholinergics. Yupelri is the long-acting type.1-3

Yupelri is a maintenance therapy for COPD. It is not used to treat COPD flare-ups that have already started. Rescue inhalers should be used for symptoms that are very severe and need rapid relief.1-3

What are the ingredients in Yupelri?

The active ingredient in Yupelri is revefenacin.1-3

How does Yupelri work?

Yupelri helps treat COPD symptoms by relaxing the muscles that surround the airways. This helps to prevent symptoms like wheezing, cough, tightness in the chest, and shortness of breath. COPD can cause irritation in the lungs that makes muscles tighten up. This can make breathing symptoms worse.1

What are the possible side effects of Yupelri?

The most common side effects of Yupelri include:2,3

  • Cough
  • Runny nose
  • Upper respiratory infection
  • Headache
  • Back pain
  • Difficulty urinating

If your breathing problems quickly worsen after taking Yupelri, contact 9-1-1 right away.

These are not all the possible side effects of Yupelri. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Yupelri.

Things to know about Yupelri

If you experience an immediate hypersensitivity such as severe itching, swelling of the mouth tongue or face, or skin rash or hives after taking Yupelri, stop taking it and seek medical help right away.2,3

Before taking Yupelri, tell your doctor if you have:2,3

  • Liver, prostate, or bladder problems
  • Eye problems like glaucoma, as this drug can make glaucoma worse

Yupelri may interact with other medicines. Before beginning treatment for COPD, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Yupelri.

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